Antiseptic Cream Formulation Using Tapinanthus globiferus Leaf Extract as Bioactive Ingredient.

Abstract

Abstract:

Cosmetic substances like creams are used to beautify and enhance the appearance of the human body in a variety of ways. They might hydrate, moisturize and soften the human skin while some combat adverse microbial activities on the skin. Herbal products are usually included in cosmetic formulations to fortify the desirable properties of creams. In this study, the leaf extract of Tapinanthus globiferus rich in secondary metabolites with antioxidant properties and antimicrobial properties was used as a bioactive ingredient to formulate an antiseptic cream for body lotion aimed at combating resilient skin infections. Cream formulation was done here as a follow-up of a previous study in this series which had verified the presence of secondary metabolites, antioxidant and antimicrobial properties of T. globiferus and reported in a previous publication. A well-designed cream specification was used to formulate the body lotion cream. The plant extract was incorporated into the formulation base to obtain an antiseptic cream with optimal factors being bees wax 4.43251 g, acetyl alcohol 3.76749 g and xanthan gum 0.3g. Physico-chemical analysis of the cream gave an optimum viscosity of 23818.6 cP, a spread of 438.32 g.cm/s, a creaming index of 0% and a pH of 6.54. The results of antimicrobial tests of the base cream without the plant extract showed that the normal cream could inhibit 24.44% of E. coli, 22.22% S. aureus, 26.67% Streptococcus and 22.22% C. albicans while the cream with the optimal concentration of the plant extract (T. globiferus) inhibited 44.44% of E. coli, 47.78% of S. aureus, 46.67% of Streptococcus and 48.89% of C. albicans. Hence the results of antimicrobial tests showed that the cream containing T. globiferus as additive was twice more destructive to microbial pathogenic species compared to the blank. Hence the plant extract from Tapinanthus globiferus is a desirable product for quality upgrade when encompassed into a cream formulation.